Diseases of Pulmonary Surfactant Homeostasis
نویسندگان
چکیده
منابع مشابه
Pulmonary surfactant
Pulmonary surfactant is a complex mixture of lipids and proteins that, by modulating surface tension during breathing, prevents alveolar collapse at exhalation and overdistention at inspiration. Surfactant is synthesized by type II pneumocytes, assembled in lamellar bodies and secreted at the air-liquid interface of the alveolus. This surface-active material is re-uptaken by alveolar type II ce...
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Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bach2) developed PAP-like accumulation of surfactant proteins in the lungs. Bach2 was expressed in A...
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Ikegami, Machiko, Timothy D. Le Cras, William D. Hardie, Mildred T. Stahlman, Jeffrey A. Whitsett, and Thomas R. Korfhagen. TGFperturbs surfactant homeostasis in vivo. Am J Physiol Lung Cell Mol Physiol 289: L34–L43, 2005. First published March 11, 2005; doi:10.1152/ajplung.00407.2004.—To determine potential relationships between transforming growth factor (TGF)and surfactant homeostasis, the m...
متن کاملEffect of pulmonary surfactant protein
The effects of surfactant-associated protein A (SPA) on lipid adsorption to the air-water interface and accumulation of dipalmitoylphosphatidylcholine (DPPC) in the surface region were investigated at 37%. Dispersions used were bovine pulmonary lipid extract surfactant with or without neutral lipid (NL). Lipid adsorption was examined with the Wilhelmy plate technique and DPPC accumulation by mo...
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ژورنال
عنوان ژورنال: Annual Review of Pathology: Mechanisms of Disease
سال: 2015
ISSN: 1553-4006,1553-4014
DOI: 10.1146/annurev-pathol-012513-104644